The effect of hypocalcemia on motor symptoms of Parkinson’s disease

Abstract Background The disabling nature of Parkinson’s disease (PD) impairs functional mobility and worsens quality life. Calcium imbalances are thought to have a significant role in the progression PD. Objective To evaluate relation between calcium deficiency deterioration PD motor symptoms. Methods A total 28 idiopathic patients were subjected symptoms evaluation using modified Hoehn–Yahr scale (H–Y) , Unified Disease Rating Scale (UPDRS) Part II III Schwab England Activities Daily Living (S–E ADL). Total ionized serum levels measured for 30 healthy control subjects. Results level was significantly lower among (4.19 mg/dl ± 0.53) than subjects (4.8 0.35) ( p < 0.0001). with hypocalcemia showed marked impairment daily life activities when compared normal regarding their scores on H–Y = 0.001), UPDRS-III UPDRS-II S–E ADL 0.001). Ionized correlated patients’ 0.019), UPDRS-Part 0.001) cutoff point detection deteriorated that presented stages more grade 2 3.99 0.037) sensitivity 80% specificity 95%. Conclusions Our findings conclude could contribute